David M. Gamm, M.D., Ph.D., is an Associate Professor of Ophthalmology and Visual Sciences and the Emmett A. Humble Distinguished Director of the McPherson Eye Research Institute at the University of Wisconsin-Madison. He also holds the Sandra Lemke Trout Chair in Eye Research, and is a member of the Waisman Center Stem Cell Research Program and the UW Stem Cell and Regenerative Medicine Center. Dr. Gamm earned his medical and doctoral degrees from the University of Michigan-Ann Arbor and completed his residency and pediatric ophthalmology fellowship at the University of Wisconsin, and was elected into the American Society for Clinical Investigation. Dr. Gamm diagnoses and manages a wide range of pediatric eye and vision disorders, including inherited retinal degenerations. However, the majority of his effort is directed toward basic and translational retinal stem cell research. The aims of his laboratory are 1) to investigate the cellular and molecular events that occur during human retinal differentiation and 2) to generate cells for use in retinal disease modeling and cell replacement therapies. To meet these goals, his lab developed a 3-dimensional optic vesicle (or retinal organoid) culture system using human ES and iPS cells, which has the capacity to model retinal development and disease, as well as to delineate the genetic “checkpoints” necessary to produce particular retinal cell types. By understanding the behavior of these cell types in vitro and in vivo, they hope to optimize strategies to delay or reverse the effects of blinding disorders such as retinitis pigmentosa and age–related macular degeneration.